Multiple mechanisms could explain how local GLP-1R signaling impairs cocaine-induced increases in extracellular DA in the LS
Consider these evidence-based dietary strategies: Eat small, frequent, low-fat meals that are easier to digest Limit sugar alcohols (sorbitol, mannitol, xylitol) found in sugar-free products, which have known laxative effects Gradually increase soluble fiber through foods like oatmeal and psyllium supplements, which can help bulk stools Avoid excessive insoluble fiber from raw vegetables and whole grains during acute episodes Stay adequately hydrated with water and electrolyte-containing beverages to prevent dehydration Avoid spicy, greasy, or very high-fiber foods during episodes of diarrhea Medication dosing may require adjustment
L-Theanine is also a smart addition to the daily routines of big-time caffeine users who sometimes get a little jittery
Research suggests that GLP-1 agonism may reduce inflammation, improve mitochondrial biogenesis, stimulate neurogenesis, exert neurotropic effects, and restore neuronal signaling 9 in the central nervous system
